Endocrine Abstracts

Brown adipocytes dissipate energy through the production of heat, acting as a defense against cold and obesity, and secrete batokines, that positively regulate metabolic functions. Thus, identifying brown-promoting molecules is crucial for developing novel therapeutic strategies against obesity and metabolic disorders. Of note, differentiation into myoblasts and later myocytes of myogenic factor 5 (Myf5) positive progenitors, the same from which brown adipocytes originate, is ...

Human malignant pleural mesothelioma (MPM) is a rare but aggressive neoplasm, arising from pleural mesothelial cells, generally due exposure to asbestos. Of note, different growth factors and their receptors are involved in the pathogenesis of MPM and resistance to therapy. Chemotherapy with cisplatin (cis) and antifolates, like pemetrexed (PEM), is the first-line treatment for inoperable MPM. Growth hormone-releasing hormone (GHRH), besides stimulating GH secretion in the ant...

Growth hormone-releasing hormone (GHRH), apart from stimulating GH secretion in the pituitary, exerts many peripheral functions, including stimulation of cell proliferation and survival. In fact, GHRH and GHRH receptors (GHRH-Rs) are expressed in different cancer cell types, where they promote proliferation and survival. Conversely, GHRH antagonists exert antineoplastic activities in several tumors, including lung cancer, one of the leading causes of death by cancer worldwide....